/* 統合オミクス研究センター — サイト共通スタイル
   配色はセンターのトンマナ（6色）に準拠 */
:root {
  --navy: #173D9D;
  --blue: #007FBF;
  --sky: #C5E5F1;
  --crimson: #C50D49;
  --pink: #F1C5D3;
  --orange: #F19D49;
  --ink: #1E2230;
  --ink-2: #33394A;
  --muted: #4A5163;
  --line: #D5DBE8;
  --grey: #F4F5F7;
  --white: #FFFFFF;
  --shadow: 0 6px 20px rgba(23, 61, 157, 0.10);
  --shadow-strong: 0 10px 28px rgba(23, 61, 157, 0.18);
  --radius: 8px;
  --font: Meiryo, "メイリオ", "Noto Sans JP", "Hiragino Sans", "Hiragino Kaku Gothic ProN", sans-serif;
  --gutter: clamp(20px, 4.5vw, 64px);
}
*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; scroll-padding-top: 96px; }
body { margin: 0; font-family: var(--font); color: var(--ink); background: var(--white); line-height: 1.8; font-size: 16px; }
img { max-width: 100%; height: auto; display: block; }
a { color: var(--navy); text-decoration: none; }
a:hover { color: var(--crimson); }
a:focus-visible, button:focus-visible, [tabindex]:focus-visible { outline: 3px solid var(--orange); outline-offset: 2px; }
h1, h2, h3, h4 { line-height: 1.45; margin: 0; }
p { margin: 0; }

.skip-link { position: absolute; left: -9999px; top: 0; background: var(--navy); color: #fff; padding: 8px 16px; z-index: 100; }
.skip-link:focus { left: 8px; top: 8px; color: #fff; }

.container { width: 100%; max-width: calc(1312px + var(--gutter) * 2); margin: 0 auto; padding: 0 var(--gutter); }
.container.narrow { max-width: calc(880px + var(--gutter) * 2); }

/* ---------- ボタン・リンク ---------- */
.btn { display: inline-flex; align-items: center; justify-content: center; gap: 10px; min-height: 52px; padding: 0 28px; border-radius: 999px; font-weight: 700; font-size: 15px; border: 2px solid transparent; transition: background .15s, color .15s, border-color .15s; }
.btn--primary { background: var(--navy); color: #fff; }
.btn--primary:hover { background: #10307e; color: #fff; }
.btn--outline { border-color: var(--navy); color: var(--navy); background: transparent; }
.btn--outline:hover { background: var(--navy); color: #fff; }
.btn--small { min-height: 44px; padding: 0 22px; font-size: 15px; }
.btn-row { display: flex; flex-wrap: wrap; gap: 14px; }
.text-link { display: inline-flex; align-items: center; gap: 6px; font-weight: 700; font-size: 14px; }

/* ---------- ヘッダー ---------- */
.site-header { position: sticky; top: 0; z-index: 50; background: #fff; box-shadow: 0 2px 12px rgba(23, 61, 157, 0.10); }
.site-header__inner { max-width: calc(1312px + var(--gutter) * 2); margin: 0 auto; padding: 0 var(--gutter); height: 88px; display: flex; align-items: center; justify-content: space-between; gap: 24px; }
.brand { display: flex; align-items: center; gap: 16px; color: var(--ink); }
.brand img { height: 52px; width: auto; }
.brand__text { display: flex; flex-direction: column; line-height: 1.4; }
.brand__aff { font-size: 12px; font-weight: 700; color: var(--muted); }
.brand__name { font-size: 21px; font-weight: 700; color: var(--navy); letter-spacing: .04em; }
.site-nav { display: flex; align-items: center; gap: 28px; font-weight: 700; font-size: 15px; }
.site-nav a:not(.btn) { color: var(--ink); padding: 6px 0; border-bottom: 3px solid transparent; }
.site-nav a:not(.btn):hover { color: var(--navy); }
.site-nav a[aria-current="page"]:not(.btn) { color: var(--navy); border-bottom-color: var(--orange); }
.nav-toggle { display: none; width: 44px; height: 44px; border: 0; background: transparent; color: var(--ink); padding: 0; cursor: pointer; align-items: center; justify-content: center; }

/* ---------- 共通セクション ---------- */
.section { padding: clamp(56px, 7vw, 96px) 0; }
.section--grey { background: var(--grey); }
.section--sky { background: var(--sky); }
.section-head { display: flex; align-items: baseline; justify-content: space-between; gap: 16px; margin-bottom: 28px; }
.section-head--split { align-items: flex-end; margin-bottom: 44px; }
.section-head--split > p { max-width: 560px; font-size: 15px; line-height: 1.9; }
.section-title { font-size: clamp(24px, 2.6vw, 30px); font-weight: 700; color: var(--navy); margin-bottom: 24px; }
.section-head .section-title { margin-bottom: 0; }
.section-title--lg { font-size: clamp(28px, 3vw, 34px); }
.sub-title { font-size: 18px; color: var(--navy); margin: 44px 0 16px; }
.eyebrow { font-size: 13px; font-weight: 700; letter-spacing: .2em; color: var(--crimson); margin-bottom: 12px; }
.eyebrow--line { display: flex; align-items: center; gap: 14px; }
.eyebrow--line::before { content: ""; width: 32px; height: 4px; background: var(--orange); flex-shrink: 0; }
.info-label { display: block; font-size: 13px; font-weight: 700; color: var(--crimson); margin-bottom: 4px; }
.note { font-size: 13px; color: var(--muted); }
.only-sp { display: none; }

/* ---------- トップ：ヒーロー ---------- */
.hero { padding: clamp(48px, 6vw, 88px) 0 clamp(56px, 7vw, 96px); }
.hero__grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 64px; align-items: center; }
.hero__text { display: flex; flex-direction: column; gap: 28px; }
.hero__text .eyebrow { margin-bottom: 0; }
.hero__title { font-size: clamp(32px, 3.6vw, 50px); line-height: 1.5; color: var(--navy); letter-spacing: .02em; }
.hero__lead { font-size: 17px; line-height: 2; color: var(--ink-2); max-width: 560px; }
.hero__visual { position: relative; padding-bottom: 80px; }
.hero__img { width: 100%; max-width: 600px; margin-left: auto; border-radius: var(--radius); aspect-ratio: 600 / 460; object-fit: cover; }
.hero__menu { position: absolute; left: 0; bottom: 0; width: 290px; background: #fff; border-radius: var(--radius); box-shadow: var(--shadow-strong); padding: 20px 24px; }
.hero__menu-label { font-size: 12px; font-weight: 700; letter-spacing: .1em; color: var(--crimson); margin-bottom: 8px; }
.hero__menu ul { list-style: none; margin: 0; padding: 0; display: flex; flex-direction: column; gap: 8px; }
.hero__menu li { display: flex; align-items: center; gap: 10px; font-size: 14px; font-weight: 700; line-height: 1.5; }
.hero__menu li::before { content: ""; width: 6px; height: 6px; border-radius: 50%; background: var(--navy); flex-shrink: 0; }

/* ---------- お知らせ ---------- */
.home-news { display: grid; grid-template-columns: repeat(12, minmax(0, 1fr)); column-gap: 32px; row-gap: 56px; }
.home-news__list { grid-column: span 7; }
.home-news__docs { grid-column: 9 / span 4; }
.news-list { list-style: none; margin: 0; padding: 0; border-top: 2px solid var(--navy); }
.news-row { display: flex; align-items: center; gap: 24px; min-height: 76px; padding: 14px 0; border-bottom: 1px solid var(--line); color: var(--ink); }
.news-row:hover .news-row__title { color: var(--navy); text-decoration: underline; }
.news-row time { width: 96px; flex-shrink: 0; font-size: 14px; color: var(--muted); font-variant-numeric: tabular-nums; }
.news-row__tag { width: 116px; flex-shrink: 0; }
.news-row__title { flex: 1; font-weight: 700; line-height: 1.6; }
.tag { display: inline-block; padding: 3px 12px; border-radius: 3px; font-size: 12px; font-weight: 700; line-height: 1.6; white-space: nowrap; }
.tag--newsletter { background: var(--navy); color: #fff; }
.tag--seminar { background: var(--crimson); color: #fff; }
.tag--paper { background: var(--sky); color: var(--navy); }
.tag--info { background: var(--grey); color: var(--ink); box-shadow: inset 0 0 0 1px var(--line); }
.pdf-badge { font-size: 12px; font-weight: 700; color: var(--crimson); border: 1.5px solid var(--crimson); padding: 1px 8px; border-radius: 3px; flex-shrink: 0; }
.doc-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 20px; }
.doc-card { display: flex; flex-direction: column; gap: 10px; color: var(--ink); }
.doc-card__thumb { position: relative; display: block; aspect-ratio: 1 / 1.414; overflow: hidden; border-radius: 6px; box-shadow: 0 6px 18px rgba(23, 61, 157, 0.18); background: #fff; }
.doc-card__thumb img { width: 100%; height: 100%; object-fit: cover; transition: transform .2s; }
.doc-card:hover .doc-card__thumb img { transform: scale(1.03); }
.doc-card__dl { position: absolute; right: 10px; bottom: 10px; width: 44px; height: 44px; border-radius: 50%; background: var(--navy); color: #fff; display: flex; align-items: center; justify-content: center; }
.doc-card__title { font-size: 14px; font-weight: 700; line-height: 1.5; }
.doc-card__meta { font-size: 12px; color: var(--muted); }
.filter { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 28px; }
.filter__btn { min-height: 44px; padding: 0 20px; border-radius: 999px; border: 2px solid var(--navy); background: #fff; color: var(--navy); font: inherit; font-size: 14px; font-weight: 700; cursor: pointer; }
.filter__btn[aria-pressed="true"] { background: var(--navy); color: #fff; }

/* ---------- 受託分析カード ---------- */
.card-grid { display: grid; gap: 24px; }
.card-grid--3 { grid-template-columns: repeat(3, minmax(0, 1fr)); }
.method-card { background: #fff; border-radius: var(--radius); overflow: hidden; box-shadow: var(--shadow); display: flex; flex-direction: column; }
.method-card__bar { height: 6px; }
.method-card__body { padding: 32px 32px 36px; display: flex; flex-direction: column; gap: 14px; flex: 1; }
.method-card__body p { flex: 1; font-size: 15px; line-height: 1.9; color: var(--ink-2); }
.method-card__label { font-size: 13px; font-weight: 700; color: var(--blue); letter-spacing: .08em; }
.method-card h3 { font-size: 21px; }
.sample-grid { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 12px; }
.sample-grid > div { background: var(--grey); border-radius: var(--radius); padding: 22px 26px; }
.sample-grid--white > div { background: #fff; }
.sample-grid p { font-size: 15px; line-height: 1.7; }

/* ---------- センターについて（トップ） ---------- */
.about-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 64px; align-items: start; }
.about-grid__text { display: flex; flex-direction: column; gap: 22px; }
.about-grid__text .eyebrow, .about-grid__text .section-title { margin-bottom: 0; }
.about-grid__text > p:not(.eyebrow) { line-height: 2; color: var(--ink-2); }
.service-grid { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 16px; }
.service-grid--2 { grid-template-columns: repeat(2, minmax(0, 1fr)); }
.service-card { background: var(--grey); border-radius: var(--radius); padding: 26px; display: flex; flex-direction: column; gap: 8px; }
.section--grey .service-card { background: #fff; box-shadow: var(--shadow); }
.service-card__no { font-size: 13px; font-weight: 700; color: var(--crimson); }
.service-card__title { font-size: 18px; color: var(--navy); }
.service-card p { font-size: 14px; line-height: 1.8; color: var(--ink-2); }
.info-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 24px; }
.info-grid p { font-size: 15px; line-height: 1.7; }
.link-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 12px; }
.link-grid a { display: flex; align-items: center; justify-content: space-between; min-height: 56px; padding: 0 20px; border: 2px solid var(--navy); border-radius: var(--radius); font-weight: 700; }
.link-grid a:hover { background: var(--navy); color: #fff; }

/* ---------- 下層ページ ---------- */
.page-head { background: var(--grey); padding: 40px 0 48px; }
.page-head--article { padding-bottom: 40px; }
.breadcrumb { font-size: 13px; color: var(--muted); margin-bottom: 20px; display: flex; flex-wrap: wrap; gap: 6px; }
.page-title { font-size: clamp(28px, 3.4vw, 40px); color: var(--navy); }
.lead { font-size: 17px; line-height: 2; color: var(--ink-2); }
.prose > * + * { margin-top: 1.2em; }
.prose h2 { font-size: 24px; color: var(--navy); margin-top: 2.2em; padding-bottom: 10px; border-bottom: 2px solid var(--sky); }
.prose h3 { font-size: 20px; color: var(--navy); margin-top: 1.8em; }
.prose h4 { font-size: 17px; margin-top: 1.6em; }
.prose ul, .prose ol { padding-left: 1.4em; }
.prose li + li { margin-top: .4em; }
.prose figure { margin: 1.6em 0; }
.prose figure img { border-radius: var(--radius); box-shadow: var(--shadow); }
.prose figcaption { font-size: 13px; color: var(--muted); margin-top: 8px; }
.prose table { width: 100%; border-collapse: collapse; }
.prose td, .prose th { padding: 12px 16px; border-bottom: 1px solid var(--line); text-align: left; vertical-align: top; }
.prose thead:empty, .prose thead tr:has(th:empty) { display: none; }
.prose td:first-child { width: 7em; font-weight: 700; color: var(--navy); white-space: nowrap; }
.prose a { text-decoration: underline; word-break: break-all; }
.marker { background: var(--pink); padding: 0 2px; }
.notes { list-style: none; padding: 0 !important; font-size: 14px; color: var(--muted); }
.cta-box { background: var(--sky); border-radius: var(--radius); padding: 32px; display: flex; flex-direction: column; gap: 20px; margin-top: 2.4em !important; }
.diagram-wrap { background: #fff; border-radius: var(--radius); box-shadow: var(--shadow); padding: 24px; overflow-x: auto; }
.diagram { width: 100%; min-width: 880px; height: auto; display: block; }
.file-list { display: flex; flex-direction: column; gap: 16px; }
.file-card { display: flex; align-items: center; gap: 20px; padding: 16px 20px; border: 2px solid var(--navy); border-radius: var(--radius); color: var(--ink); text-decoration: none !important; }
.file-card:hover { background: var(--grey); color: var(--ink); }
.file-card__thumb { width: 64px; height: auto; border-radius: 3px; box-shadow: 0 3px 10px rgba(23, 61, 157, 0.18); }
.file-card__icon { width: 64px; height: 80px; border-radius: 4px; display: flex; align-items: center; justify-content: center; font-size: 13px; font-weight: 700; color: #fff; flex-shrink: 0; }
.file-card__icon--xlsx { background: var(--blue); }
.file-card__text { flex: 1; display: flex; flex-direction: column; gap: 2px; }
.file-card__title { font-weight: 700; }
.file-card__meta { font-size: 13px; color: var(--muted); }
.file-card__dl { width: 44px; height: 44px; border-radius: 50%; background: var(--navy); color: #fff; display: flex; align-items: center; justify-content: center; flex-shrink: 0; }
.step-list { list-style: none; counter-reset: step; margin: 40px 0 24px; padding: 0; display: flex; flex-direction: column; gap: 12px; }
.step-list li { counter-increment: step; position: relative; background: var(--grey); border-radius: var(--radius); padding: 20px 24px 20px 88px; display: flex; flex-direction: column; gap: 4px; min-height: 72px; justify-content: center; }
.step-list li::before { content: counter(step, decimal-leading-zero); position: absolute; left: 24px; top: 50%; transform: translateY(-50%); font-size: 24px; font-weight: 700; color: var(--navy); }
.step-list__title { font-weight: 700; font-size: 17px; }
.step-list__desc { font-size: 14px; color: var(--ink-2); }
.step-list__desc a { margin-left: .5em; font-weight: 700; }
.biblio { list-style: none; padding: 0 !important; display: flex; flex-direction: column; gap: 4px; }
.biblio li { padding: 16px 0; border-bottom: 1px solid var(--line); font-size: 14px; line-height: 1.8; margin: 0 !important; }
.biblio__topic { display: block; font-weight: 700; color: var(--navy); font-size: 15px; margin-bottom: 4px; }
.staff-group + .staff-group { margin-top: 48px; }
.staff-group__title { font-size: 18px; color: var(--crimson); margin-bottom: 16px; }
.staff-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 16px; }
.staff { background: var(--grey); border-radius: var(--radius); padding: 22px 26px; display: flex; flex-direction: column; gap: 4px; }
.staff__name { font-size: 20px; font-weight: 700; color: var(--navy); }
.staff__role { font-size: 14px; color: var(--ink-2); }
.table-wrap { overflow-x: auto; }
.comp-table th[scope="row"] { width: 10em; color: var(--navy); white-space: normal; }
.comp-table thead th { background: var(--navy); color: #fff; }
.comp-table td { font-size: 14px; }
.comp-table td:first-child { width: auto; font-weight: 400; color: inherit; white-space: normal; }
.contact-box { background: var(--sky); border-radius: var(--radius); padding: 32px; }
.contact-box__mail { font-size: clamp(18px, 2.4vw, 24px); font-weight: 700; color: var(--navy); margin: 4px 0 12px !important; word-break: break-all; }

/* 記事ページ */
.article-meta { display: flex; align-items: center; gap: 14px; font-size: 14px; color: var(--muted); margin-bottom: 14px; }
.section--article { padding-top: 48px; }
.pdf-card { display: flex; align-items: center; gap: 28px; margin-top: 40px; padding: 20px; border: 2px solid var(--navy); border-radius: var(--radius); color: var(--ink); }
.pdf-card:hover { background: var(--grey); color: var(--ink); }
.pdf-card__thumb { width: 150px; border-radius: 4px; box-shadow: 0 6px 18px rgba(23, 61, 157, 0.18); flex-shrink: 0; }
.pdf-card__text { flex: 1; display: flex; flex-direction: column; gap: 6px; }
.pdf-card__meta { font-size: 12px; font-weight: 700; color: var(--crimson); letter-spacing: .1em; }
.pdf-card__title { font-size: 20px; font-weight: 700; }
.pdf-card__hint { font-size: 14px; color: var(--muted); }
.pdf-card__btn { flex-shrink: 0; }
.pager { display: flex; justify-content: space-between; gap: 16px; margin-top: 48px; padding-top: 24px; border-top: 1px solid var(--line); font-size: 14px; font-weight: 700; }

/* ---------- フッター ---------- */
.site-footer { background: var(--navy); color: #fff; padding: 72px 0 32px; font-size: 14px; line-height: 1.8; }
.site-footer a { color: #fff; text-decoration: underline; }
.site-footer__grid { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 48px; }
.site-footer__aff { font-size: 12px; font-weight: 700; }
.site-footer__name { font-size: 24px; font-weight: 700; letter-spacing: .04em; }
.site-footer__en { font-size: 13px; }
.site-footer__label { font-weight: 700; color: var(--sky); margin-bottom: 6px; }
.site-footer__bottom { margin-top: 48px; padding-top: 24px; border-top: 1px solid rgba(197, 229, 241, 0.4); display: flex; justify-content: space-between; flex-wrap: wrap; gap: 16px; font-size: 12px; }
.site-footer__bottom nav { display: flex; flex-wrap: wrap; gap: 8px 20px; }
.site-footer__bottom nav a { text-decoration: none; }

/* ---------- レスポンシブ ---------- */
@media (max-width: 1180px) {
  .site-nav { gap: 20px; font-size: 14px; }
  .brand__aff { display: none; }
}
@media (max-width: 960px) {
  html { scroll-padding-top: 76px; }
  .site-header__inner { height: 68px; }
  .brand img { height: 40px; }
  .brand__name { font-size: 17px; }
  .nav-toggle { display: inline-flex; }
  .site-nav { display: none; position: absolute; top: 68px; left: 0; right: 0; background: #fff; flex-direction: column; align-items: stretch; gap: 0; padding: 8px var(--gutter) 24px; box-shadow: 0 12px 24px rgba(23, 61, 157, 0.14); }
  .site-header.is-open .site-nav { display: flex; }
  .site-nav a:not(.btn) { padding: 14px 0; border-bottom: 1px solid var(--line); }
  .site-nav a[aria-current="page"]:not(.btn) { border-bottom-color: var(--line); color: var(--crimson); }
  .site-nav .btn { margin-top: 16px; }
  .hero__grid, .about-grid { grid-template-columns: 1fr; gap: 40px; }
  .hero__visual { order: -1; padding-bottom: 0; }
  .hero__img { max-width: none; }
  .hero__menu { position: static; width: auto; margin-top: -32px; margin-left: 16px; margin-right: 16px; }
  .home-news__list, .home-news__docs { grid-column: 1 / -1; }
  .home-news__docs { max-width: 480px; }
  .card-grid--3 { grid-template-columns: 1fr; }
  .sample-grid, .service-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .section-head--split { flex-direction: column; align-items: flex-start; }
  .site-footer__grid { grid-template-columns: 1fr; gap: 28px; }
  .only-sp { display: block; }
}
@media (max-width: 640px) {
  .news-row { flex-wrap: wrap; gap: 6px 12px; }
  .news-row time { width: auto; }
  .news-row__tag { width: auto; }
  .news-row__title { flex-basis: 100%; }
  .news-row .pdf-badge { display: none; }
  .sample-grid, .service-grid, .service-grid--2, .info-grid, .staff-grid, .link-grid { grid-template-columns: 1fr; }
  .pdf-card { flex-direction: column; align-items: flex-start; gap: 16px; }
  .pdf-card__thumb { width: 120px; }
  .pdf-card__btn { width: 100%; }
  .file-card { gap: 14px; padding: 14px; }
  .step-list li { padding-left: 72px; }
  .step-list li::before { left: 18px; font-size: 20px; }
  .prose td:first-child { width: 5em; }
}
@media (prefers-reduced-motion: reduce) { * { transition: none !important; } }

/* メニュー項目が増えたため、幅1320px以下ではメニューボタン式に切り替え */
@media (max-width: 1320px) {
  .nav-toggle { display: inline-flex; }
  .site-nav { display: none; position: absolute; top: 100%; left: 0; right: 0; background: #fff; flex-direction: column; align-items: stretch; gap: 0; padding: 8px var(--gutter) 24px; box-shadow: 0 12px 24px rgba(23, 61, 157, 0.14); }
  .site-header.is-open .site-nav { display: flex; }
  .site-nav a:not(.btn) { padding: 14px 0; border-bottom: 1px solid var(--line); }
  .site-nav a[aria-current="page"]:not(.btn) { border-bottom-color: var(--line); color: var(--crimson); }
  .site-nav .btn { margin-top: 16px; }
}